Onset of Quiescence Following p53 Mediated Down-Regulation of H2AX in Normal Cells

@article{Atsumi2011OnsetOQ,
  title={Onset of Quiescence Following p53 Mediated Down-Regulation of H2AX in Normal Cells},
  author={Yuko Atsumi and H. Fujimori and H. Fukuda and Aki Inase and Keitaro Shinohe and Y. Yoshioka and M. Shikanai and Yosuke Ichijima and J. Unno and S. Mizutani and N. Tsuchiya and Y. Hippo and H. Nakagama and M. Masutani and H. Teraoka and Ken-ichi Yoshioka},
  journal={PLoS ONE},
  year={2011},
  volume={6}
}
  • Yuko Atsumi, H. Fujimori, +13 authors Ken-ichi Yoshioka
  • Published 2011
  • Medicine, Biology
  • PLoS ONE
  • Normal cells, both in vivo and in vitro, become quiescent after serial cell proliferation. During this process, cells can develop immortality with genomic instability, although the mechanisms by which this is regulated are unclear. Here, we show that a growth-arrested cellular status is produced by the down-regulation of histone H2AX in normal cells. Normal mouse embryonic fibroblast cells preserve an H2AX diminished quiescent status through p53 regulation and stable-diploidy maintenance… CONTINUE READING

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