Onset of Effect of 5‐HT1B/1D Agonists: A Model With Pharmacokinetic Validation

@article{Fox2004OnsetOE,
  title={Onset of Effect of 5‐HT1B/1D Agonists: A Model With Pharmacokinetic Validation},
  author={Anthony W Fox},
  journal={Headache: The Journal of Head and Face Pain},
  year={2004},
  volume={44}
}
  • A. Fox
  • Published 1 February 2004
  • Medicine
  • Headache: The Journal of Head and Face Pain
Objective.—To quantitate onset of effect of all formulations of sumatriptan, and to investigate whether this is related to rate, not extent, of drug absorption. 
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38 Citations
Highly Influential Citations
1
Background Citations
16
Methods Citations
3

38 Citations

Resolution of Concentration–Response Differences in Onset of Effect Between Subcutaneous and Oral Sumatriptan
TLDR
Whether the concentration–response relationships for onset of effect of oral and subcutaneous sumatriptan differ, and if so, then to explore whether a single model for the onset ofeffect can nonetheless be found for multiple dose sizes and both routes of administration.
Rapid Oral Transmucosal Absorption of Sumatriptan, and Pharmacodynamics in Acute Migraine
TLDR
Whether sumatriptan can be absorbed across the oral mucosa, and, if so, whether there are pharmacodynamic correlates of such pharmacokinetics in patients experiencing migraine attacks, is investigated.
Improved Pharmacokinetics of Sumatriptan With Breath Powered™ Nasal Delivery of Sumatriptan Powder
TLDR
The purpose of this study was to directly compare the pharmacokinetic (PK) profile of 22‐mg sumatriptan powder delivered intranasally with a novel Breath Powered™ device against a 20‐mg liquid nasal spray, a 100‐mg oral tablet, and a 6‐mg subcutaneous injection.
Theory-based analysis of clinical efficacy of triptans using receptor occupancy
TLDR
Receptor occupancy can be used as a parameter for a common index to evaluate the therapeutic effect and provide useful information to support the proper use of triptans.
Rapid absorption of sumatriptan powder and effects on glyceryl trinitrate model of headache following intranasal delivery using a novel bi‐directional device
TLDR
The pharmacokinetics of intranasal sumatriptan (administered using a novel bi‐directional powder delivery device) and its effects on quantitative electroencephalography in patients with migraine were investigated.
Why pharmacokinetic differences among oral triptans have little clinical importance: a comment
TLDR
If no oral formulations are found that can allow more predictable pharmacokinetics, the same problems will probably also arise with new classes of drugs for the acute treatment of migraine.
Selective reduction in the expression of UGTs and SULTs, a novel mechanism by which piperine enhances the bioavailability of curcumin in rat
TLDR
It is concluded that piperine pre‐treatment time‐dependently improves the bioavailability of curcumin through the reversible and selective inhibition of UGTs and SULTs.
nhanced oral bioavailability of docetaxel in rats by four consecutive days of retreatment with curcumin
TLDR
In order to improve the oral bioavailability of docetaxel, a component of turmeric, curcumin, which can down-regulate the intestinal P-glycoprotein and CYP3A protein levels, was used for the pre-treatment of rats before the oral administration of docentaxel.
Interindividual variability of oral sumatriptan pharmacokinetics and of clinical response in migraine patients
TLDR
The slow rate and low extent of absorption of the drug during the first 2 h after dosing observed in patients of group B could explain their unsatisfactory response to oral sumatriptan.
Prediction of Headache Response in Migraine Treatment
TLDR
The objective of this investigation was to develop a disease model to predict measures of headache in randomized placebo-controlled clinical trials investigating oral sumatriptan as a paradigm compound and demonstrate the value of combining pharmacokinetic and efficacy information to model disease and characterize time-independent drug properties in a population of migraineurs.
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