Onset coding is degraded in auditory nerve fibers from mutant mice lacking synaptic ribbons.

@article{Buran2010OnsetCI,
  title={Onset coding is degraded in auditory nerve fibers from mutant mice lacking synaptic ribbons.},
  author={Bradley N Buran and Nicola Strenzke and Andreas Neef and Eckart D. Gundelfinger and Tobias Moser and M Charles Liberman},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2010},
  volume={30 22},
  pages={7587-97}
}
Synaptic ribbons, found at the presynaptic membrane of sensory cells in both ear and eye, have been implicated in the vesicle-pool dynamics of synaptic transmission. To elucidate ribbon function, we characterized the response properties of single auditory nerve fibers in mice lacking Bassoon, a scaffolding protein involved in anchoring ribbons to the membrane. In bassoon mutants, immunohistochemistry showed that fewer than 3% of the hair cells' afferent synapses retained anchored ribbons… CONTINUE READING
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The relationship between spike rate and synchrony in responses of auditory-nerve fibers to single tones

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