Onset and time course of antidepressant action: psychopharmacological implications of a controlled trial of electroconvulsive therapy

@article{Segman1995OnsetAT,
  title={Onset and time course of antidepressant action: psychopharmacological implications of a controlled trial of electroconvulsive therapy},
  author={Ronnen H. Segman and Malka Gorfine and Bernard Lerer and Baruch Shapira},
  journal={Psychopharmacology},
  year={1995},
  volume={119},
  pages={440-448}
}
Onset and time course of antidepressant effect were examined in 47 patients with major depressive disorder who had been randomly assigned to twice weekly bilateral, brief pulse electroconvulsive therapy plus one simulated treatment per week (ECT×2) or to a three times weekly schedule of administration (ECT×3). Rapid improvement was observed in the ECT×3 group in whom the number of real ECTs to 30% reduction on the Hamilton Depression Scale (HAM-D) was 3.2±1.90, administered over 7.3±4.43 days… CONTINUE READING
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