Only the soluble form of the scavenger receptor CD163 acts inhibitory on phorbol ester‐activated T‐lymphocytes, whereas membrane‐bound protein has no effect

@article{Frings2002OnlyTS,
  title={Only the soluble form of the scavenger receptor CD163 acts inhibitory on phorbol ester‐activated T‐lymphocytes, whereas membrane‐bound protein has no effect},
  author={Werner Frings and Jens Dreier and Clemens Prof. Dr. Sorg},
  journal={FEBS Letters},
  year={2002},
  volume={526}
}
CD163: a regulated hemoglobin scavenger receptor with a role in the anti‐inflammatory response
TLDR
Recent data indicate that solubleCD163 may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions and a role for soluble CD163 in immune suppression has been proposed.
Interaction of soluble CD163 with activated T lymphocytes involves its association with non‐muscle myosin heavy chain type A
TLDR
The results suggest that sCD163 associates with cellular myosin, thereby possibly modulating the cells’ response to an inflammatory stimulus.
Scavenger receptor CD163 and its biological functions.
TLDR
It seems apparent that CD163 scavenger receptor can be used as biomarker in different diseases and as a valuable diagnostic parameter for prognosis of many diseases especially inflammatory disorders and sepsis.
Scavenger Receptor CD163 and Its Biological Functions.
TLDR
It seems apparent that CD163 scavenger receptor can be used as biomarker in different diseases and as a valuable diagnostic parameter for prognosis of many diseases especially inflammatory disorders and sepsis.
TGF‐β regulation of human macrophage scavenger receptor CD163 is Smad3‐dependent
TLDR
It is demonstrated that transforming growth factor‐β markedly reduces expression of CD163, a macrophage‐specific member of the scavenger receptor cysteine‐rich family, and this results define a novel function for TGF‐β and implicate an important role for CD163 in the host response to inflammation.
Soluble CD163
  • H. Møller
  • Biology, Medicine
    Scandinavian journal of clinical and laboratory investigation
  • 2012
TLDR
It is now evident that sCD163 is very useful as a biomarker of macrophages activation in various inflammatory diseases, such as macrophage activation syndrome, sepsis, and liver disease, and is a general risk marker of comorbidity and mortality in several chronic inflammatory disease states.
...
...

References

SHOWING 1-10 OF 22 REFERENCES
Soluble CD163 inhibits phorbol ester-induced lymphocyte proliferation.
TLDR
A potential direct anti-inflammatory effect mediated by soluble CD163 is identified and statistically significantly inhibits phorbol ester-induced human T-lymphocyte activation, thus attenuating the immune response to the inflammatory mediator.
Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro‐ and antiinflammatory stimuli
TLDR
The results demonstrate that CD163 expression in monocytes/macrophages is regulated by proinflammatory and antiinflammatory mediators, implying a functional role of CD163 in the antiinflammatory response of monocytes.
Shedding of CD163, a novel regulatory mechanism for a member of the scavenger receptor cysteine-rich family.
TLDR
It is suggested that PMA-induced activation of PKC leads to protease-mediated shedding of CD163, indicating a specific release mechanism of soluble CD163 by human monocytes which could play an important role in modulating inflammatory processes.
Identification of the hemoglobin scavenger receptor/CD163 as a natural soluble protein in plasma.
TLDR
SHbSR is an abundant plasma protein potentially valuable in monitoring patients with infections and myelomonocytic leukemia and there are strong indications that HbSR serves an anti-inflammatory function.
Integrin‐dependent role of human T cell matrix metalloproteinase activity in chemotaxis through a model basement membrane
TLDR
Specific beta1 integrins thus mediate interactions of stimulated T cells with basement membranes, including adherence, localized digestion by MMPs, and chemotactic passage, that promote entry of T cells into extravascular tissues.
Human monocytes express CD163, which is upregulated by IL-10 and identical to p155.
TLDR
It is shown that >99% of all CD14 positive monocytes express CD163 and that monocyte derived dendritic cells express low levels of CD163, and that IL-10, like glucocorticoid-inducible member of the scavenger receptor cysteine-rich family of proteins, induces high CD163 expression on cultured human monocytes.
Alternatively activated macrophages actively inhibit proliferation of peripheral blood lymphocytes and CD4+ T cells in vitro
TLDR
Results show that aaMΦ actively inhibit mitogen‐mediated proliferation of PBL and CD4+ T’cells independently of the expression of costimulatory molecules and of IL‐10, NO or prostaglandin synthesis, and that inhibition of phenotypic differentiation of aa MΦ is paralleled by a lack of functional maturation.
A new macrophage differentiation antigen which is a member of the scavenger receptor superfamily
TLDR
The antibodies Ki‐M8, Ber‐Mac3, GHI/61 and SM4 define a human macrophage‐associated antigen with a relative molecular mass of 130000 which the authors designate M130, and the membrane protein encoded contains a leader peptide of 40 residues, a putative extracellular domain of 1003 residues, followed by a hydrophobic segment of 24 residues and a cytoplasmic domain of 49 residues.
Identification of the haemoglobin scavenger receptor
TLDR
The identification of the acute phase-regulated and signal-inducing macrophage protein, CD163, as a receptor that scavenges haemoglobin by mediating endocytosis of haptoglobin–haemoglobin complexes is reported.
...
...