Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding.

@article{HronMilhavet2006OnlyAI,
  title={Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding.},
  author={Lisa H{\'e}ron-Milhavet and Celine Franckhauser and Vanessa Rana and Cyril Berthenet and Daniel G Fisher and Brian A. Hemmings and Anne Fernandez and Ned J. C. Lamb},
  journal={Molecular and cellular biology},
  year={2006},
  volume={26 22},
  pages={8267-80}
}
Protein kinase B (PKB/Akt) is an important modulator of insulin signaling, cell proliferation, and survival. Using small interfering RNA duplexes in nontransformed mammalian cells, we show that only Akt1 is essential for cell proliferation, while Akt2 promotes cell cycle exit. Silencing Akt1 resulted in decreased cyclin A levels and inhibition of S-phase entry, effects not seen with Akt2 knockdown and specifically rescued by microinjection of Akt1, not Akt2. In differentiating myoblasts, Akt2… CONTINUE READING
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