Online tool to guide decisions for BRCA1/2 mutation carriers.

@article{Kurian2012OnlineTT,
  title={Online tool to guide decisions for BRCA1/2 mutation carriers.},
  author={Allison W. Kurian and Diego F. Mu{\~n}oz and Peter Rust and Elizabeth A. Schackmann and Michael J A Smith and Lauren Clarke and Meredith A. Mills and Sylvia K Plevritis},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2012},
  volume={30 5},
  pages={497-506}
}
PURPOSE Women with BRCA1 or BRCA2 (BRCA1/2) mutations must choose between prophylactic surgeries and screening to manage their high risks of breast and ovarian cancer, comparing options in terms of cancer incidence, survival, and quality of life. A clinical decision tool could guide these complex choices. METHODS We built a Monte Carlo model for BRCA1/2 mutation carriers, simulating breast screening with annual mammography plus magnetic resonance imaging (MRI) from ages 25 to 69 years and… CONTINUE READING
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