Online solid phase extraction and liquid chromatography-mass spectrometric determination of nucleoside drugs in plasma.

@article{Wang2016OnlineSP,
  title={Online solid phase extraction and liquid chromatography-mass spectrometric determination of nucleoside drugs in plasma.},
  author={Man Wang and Ping Ma and Xiaonan Xi and Lei Liu and Yabin Wen and Kangning Liu and Liang Sun and Yaxin Lu and Zheng Yin},
  journal={Talanta},
  year={2016},
  volume={161},
  pages={278-287}
}
The bioanalysis and especially the sample preparation of nucleoside drugs in complex media, such as human plasma, has been challenging due to the high polarity and high solubility of these drugs in water. Online solid phase extraction (SPE) offers significant advantages, such as automation and timesaving. Thus, several types of SPE columns have been developed for compounds with different polarities. In this study, SPE was applied to overcome the issue of sample pretreatment of nucleoside drugs… CONTINUE READING