Ongoing in vivo immunoglobulin class switch DNA recombination in chronic lymphocytic leukemia B cells.

@article{Cerutti2002OngoingIV,
  title={Ongoing in vivo immunoglobulin class switch DNA recombination in chronic lymphocytic leukemia B cells.},
  author={Andrea Cerutti and Hong Zan and Edmund C. Kim and Shefali Shah and Elaine J. Schattner and Andr{\'a}s Schaffer and Paolo Casali},
  journal={Journal of immunology},
  year={2002},
  volume={169 11},
  pages={6594-603}
}
Chronic lymphocytic leukemia (CLL) results from the expansion of malignant CD5(+) B cells that usually express IgD and IgM. These leukemic cells can give rise in vivo to clonally related IgG(+) or IgA(+) elements. The requirements and modalities of this process remain elusive. Here we show that leukemic B cells from 14 of 20 CLLs contain the hallmarks of… CONTINUE READING