Ongoing enterovirus-induced myocarditis is associated with persistent heart muscle infection: quantitative analysis of virus replication, tissue damage, and inflammation.

@article{Klingel1992OngoingEM,
  title={Ongoing enterovirus-induced myocarditis is associated with persistent heart muscle infection: quantitative analysis of virus replication, tissue damage, and inflammation.},
  author={Karin Klingel and Christine Hohenadl and Annie Canu and Mario Albrecht and Mark Seemann and Gerhard Mall and Reinhard Kandolf},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 1},
  pages={314-8}
}
Coxsackievirus B3-induced myocarditis in different immunocompetent mouse strains was used as a model to investigate interrelationships between virus replication and development of chronic enteroviral heart disease. Using in situ hybridization to detect enteroviral RNA, we show that heart muscle infection is not only detected in acute myocarditis but is also detected during the chronic phase of the disease. Coxsackievirus B3 could evade immunological surveillance in a host-dependent fashion… CONTINUE READING

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