Ongoing Adaptive Evolution of ASPM, a Brain Size Determinant in Homo sapiens

  title={Ongoing Adaptive Evolution of ASPM, a Brain Size Determinant in Homo sapiens},
  author={N. Mekel-Bobrov and S. L. Gilbert and P. Evans and E. Vallender and J. R. Anderson and R. Hudson and S. Tishkoff and B. Lahn},
  pages={1720 - 1722}
  • N. Mekel-Bobrov, S. L. Gilbert, +5 authors B. Lahn
  • Published 2005
  • Medicine, Biology
  • Science
  • The gene ASPM (abnormal spindle-like microcephaly associated) is a specific regulator of brain size, and its evolution in the lineage leading to Homo sapiens was driven by strong positive selection. Here, we show that one genetic variant of ASPM in humans arose merely about 5800 years ago and has since swept to high frequency under strong positive selection. These findings, especially the remarkably young age of the positively selected variant, suggest that the human brain is still undergoing… CONTINUE READING

    Topics from this paper.

    Cytoskeletal genes regulating brain size.
    • 132
    Microcephaly genes evolved adaptively throughout the evolution of eutherian mammals
    • 20
    • PDF
    Evolution of ASPM coding variation in apes and associations with brain structure in chimpanzees
    Phylogenetic Analysis of ASPM, a Major Contributor Gene of Microcephaly
    • 3
    • PDF
    Molecular evolution of the brain size regulator genes CDK5RAP2 and CENPJ.
    • 82


    Publications referenced by this paper.