Ongoing Adaptive Evolution of ASPM, a Brain Size Determinant in Homo sapiens

@article{MekelBobrov2005OngoingAE,
  title={Ongoing Adaptive Evolution of ASPM, a Brain Size Determinant in Homo sapiens},
  author={N. Mekel-Bobrov and S. L. Gilbert and P. Evans and E. Vallender and Jeffrey R. Anderson and R. Hudson and S. Tishkoff and B. Lahn},
  journal={Science},
  year={2005},
  volume={309},
  pages={1720 - 1722}
}
The gene ASPM (abnormal spindle-like microcephaly associated) is a specific regulator of brain size, and its evolution in the lineage leading to Homo sapiens was driven by strong positive selection. Here, we show that one genetic variant of ASPM in humans arose merely about 5800 years ago and has since swept to high frequency under strong positive selection. These findings, especially the remarkably young age of the positively selected variant, suggest that the human brain is still undergoing… Expand

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References

SHOWING 1-10 OF 50 REFERENCES
Genetic links between brain development and brain evolution
ASPM is a major determinant of cerebral cortical size
Signatures of natural selection in the human genome
Genetic Structure of the Ancestral Population of Modern Humans
Evolution of the brain and intelligence
Genetic Structure of Human Populations
...
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2
3
4
5
...