One-step synthesis of 2-keto-3-deoxy-d-gluconate by biocatalytic dehydration of d-gluconate.

@article{Matsubara2014OnestepSO,
  title={One-step synthesis of 2-keto-3-deoxy-d-gluconate by biocatalytic dehydration of d-gluconate.},
  author={K. Matsubara and R. K{\"o}hling and B. Sch{\"o}nenberger and T. Kouril and D. Esser and C. Br{\"a}sen and B. Siebers and Roland Wohlgemuth},
  journal={Journal of biotechnology},
  year={2014},
  volume={191},
  pages={
          69-77
        }
}
2-Keto-3-deoxy-sugar acids are key intermediates of central metabolism and integral constituents of bacterial (lipo)polysaccharides and cell wall components and are therefore continuously and highly demanded in related research fields. The stereospecific chemical synthesis of chiral 2-keto-deoxy-sugar acids involves a multitude of reaction steps, while in metabolic pathways only few conversions lead to the same 2-keto-3-deoxy sugar acids from easily available carbohydrate precursors. Here we… Expand
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