One-step semisynthesis method of spirocurcasone and pyracurcasone from curcusones A and B.

  title={One-step semisynthesis method of spirocurcasone and pyracurcasone from curcusones A and B.},
  author={Xu-Yang Li and Yuan-Feng Yang and Xingrong Peng and Ming-Ming Li and Liang-qun Li and Xu Deng and Hong-Bo Qin and Jie-Qing Liu and Minghua Qiu},
  journal={Organic letters},
  volume={16 8},
High contents of curcusones A and B and trace amounts of spirocurcasone exist in the roots of Jatropha curcas. Here, a one-step semisynthesis method of spirocurcasone and pyracurcasone was built, not only resulted an increased yield of spirocurcasone but also produced pyracurcasone, which exhibited greater cytotoxicity compared to curcusones A and B. The plausible mechanism of the formation of pyracurcasone was proposed, and the proposed biogenetic origin for spirocurcasone by Taglialatela… 
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