One-step nucleic acid amplification for detecting lymph node metastasis of head and neck squamous cell carcinoma.

@article{Goda2012OnestepNA,
  title={One-step nucleic acid amplification for detecting lymph node metastasis of head and neck squamous cell carcinoma.},
  author={Hiroyuki Goda and Koh‐ichi Nakashiro and Ryota Oka and Hiroshi Tanaka and Hiroyuki Wakisaka and Naohito Hato and Masamitsu Hyodo and Hiroyuki Hamakawa},
  journal={Oral oncology},
  year={2012},
  volume={48 10},
  pages={
          958-963
        }
}
OBJECTIVES Lymph node stage is an important prognostic factor in head and neck squamous cell carcinoma (HNSCC). We previously reported the clinical usefulness of sentinel lymph node biopsy diagnosed by genetic analysis using quantitative RT-PCR. However, this method takes about 3h. In this study, we attempted to develop a more efficient method for the intraoperative genetic detection of lymph node metastasis in HNSCC. MATERIALS AND METHODS A total of 312 lymph nodes (65 patients) were… CONTINUE READING
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