One-step nucleic acid amplification (OSNA): where do we go with it?

  title={One-step nucleic acid amplification (OSNA): where do we go with it?},
  author={Yasuhiro Tamaki},
  journal={International Journal of Clinical Oncology},
The one-step nucleic acid amplification (OSNA) assay was initially developed for the intraoperative assessment of sentinel lymph node metastases in breast cancer. This assay measures cytokeratin 19 (CK19) mRNA copy number and is widely used in hospitals. The results of the IBCSG 23-01, ACOSOG Z0011, and AMAROS trials demonstrated that no further axillary dissection is required for patients with sentinel lymph nodes that tested positive for cancer, which has led to a decreasing trend in the need… CONTINUE READING
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