One-step high-radiochemical-yield synthesis of [18F]FP-CIT using a protic solvent system.

@article{Lee2007OnestepHS,
  title={One-step high-radiochemical-yield synthesis of [18F]FP-CIT using a protic solvent system.},
  author={Soonhee Lee and Seung Jun Oh and David Y. K Chi and Se Hun Kang and Hee Seup Kil and Jae Seung Kim and Dae Hyuk Moon},
  journal={Nuclear medicine and biology},
  year={2007},
  volume={34 4},
  pages={
          345-51
        }
}
Although [18F] fluoropropylcarbomethoxyiodophenylnortropane (FP-CIT) is a promising radiopharmaceutical for dopamine transporter imaging, it has not been used for clinical studies because of low radiochemical yield. The purpose of our study was to develop a new radiochemistry method using a protic solvent system to obtain a high radiochemical yield of [18F]FP-CIT in single-step manual and automatic preparation procedures. [18F]F(-) was trapped on a QMA Sep-Pak cartridge or PS-HCO(3) cartridge… CONTINUE READING
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