• DOI:10.1016/J.TETLET.2011.09.112
Corpus ID: 58373

One-step double reduction of aryl nitro and carbonyl groups using hydrazine

@article{DiezCecilia2011OnestepDR,
  title={One-step double reduction of aryl nitro and carbonyl groups using hydrazine},
  author={Elena Diez-Cecilia and Brendan D. Kelly and I. Rozas},
  journal={Tetrahedron Letters},
  year={2011},
  volume={52},
  pages={6702-6704}
}

• Elena Diez-Cecilia, Brendan D. Kelly, I. Rozas
• Published 2011
• Chemistry
• Tetrahedron Letters

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a b s t r a c t Single-step reduction of aryl nitro and carbonyl groups to the corresponding synthetically useful alkylanilines occurs with excellent yields by treatment with hydrazine and a base in a solvent-free reaction. The method has been applied to a broad range of compounds with different properties. Investigations into the mechanism of the reduction reveal that each group is reduced independently. A mechanism is proposed for this novel reduction of aromatic nitro groups.