One-stage design is empirically more powerful than two-stage design for family-based genome-wide association studies

@article{Rohlfs2007OnestageDI,
  title={One-stage design is empirically more powerful than two-stage design for family-based genome-wide association studies},
  author={Rori V. Rohlfs and Chelsea M. Taylor and Lucia Mirea and Shelley B. Bull and MargaretJ. Corey and Amy D. Anderson},
  journal={BMC Proceedings},
  year={2007},
  volume={1},
  pages={S137 - S137}
}
Finding a genetic marker associated with a trait is a classic problem in human genetics. Recently, two-stage approaches have gained popularity in marker-trait association studies, in part because researchers hope to reduce the multiple testing problem by testing fewer markers in the final stage. We compared one two-stage family-based approach to an analogous single-stage method, calculating the empirical type I error rates and power for both methods using fully simulated data sets modeled on… CONTINUE READING
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