One-shot genetic analysis in monolithic Silicon/Pyrex microdevices.

@article{Potrich2012OneshotGA,
  title={One-shot genetic analysis in monolithic Silicon/Pyrex microdevices.},
  author={Cristina Potrich and Lorenzo Lunelli and Laura Pasquardini and D Sonn and Diego Vozzi and Ramona Dallapiccola and L Marocchi and Ivan Ferrante and O Rossotto and Cecilia Pederzolli},
  journal={Biomedical microdevices},
  year={2012},
  volume={14 6},
  pages={1103-13}
}
Modern Lab-on-a-chip (LOC) platforms for genomic applications integrate several biological tasks in a single device. Combination of these processes into a single device minimizes sample loss and contamination problems as well as reducing analysis time and costs. Here we present a study of a microchip platform aimed at analyzing issues arising from the combination of different functions, such as DNA purification from blood, target amplification by PCR and DNA detection in a single silicon-based… CONTINUE READING