One sequence, two ribozymes: implications for the emergence of new ribozyme folds.

@article{Schultes2000OneST,
  title={One sequence, two ribozymes: implications for the emergence of new ribozyme folds.},
  author={Erik A. Schultes and David P. Bartel},
  journal={Science},
  year={2000},
  volume={289 5478},
  pages={448-52}
}
We describe a single RNA sequence that can assume either of two ribozyme folds and catalyze the two respective reactions. The two ribozyme folds share no evolutionary history and are completely different, with no base pairs (and probably no hydrogen bonds) in common. Minor variants of this sequence are highly active for one or the other reaction, and can be accessed from prototype ribozymes through a series of neutral mutations. Thus, in the course of evolution, new RNA folds could arise from… CONTINUE READING
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