One process for pancreatic beta-cell coalescence into islets involves an epithelial-mesenchymal transition.

@article{Cole2009OnePF,
  title={One process for pancreatic beta-cell coalescence into islets involves an epithelial-mesenchymal transition.},
  author={Lori Cole and Miranda Anderson and Parker B. Antin and Sean W Limesand},
  journal={The Journal of endocrinology},
  year={2009},
  volume={203 1},
  pages={19-31}
}
Islet replacement is a promising therapy for treating diabetes mellitus, but the supply of donor tissue for transplantation is limited. To overcome this limitation, endocrine tissue can be expanded, but this requires an understanding of normal developmental processes that regulate islet formation. In this study, we compare pancreas development in sheep and human, and provide evidence that an epithelial-mesenchymal transition (EMT) is involved in beta-cell differentiation and islet formation… CONTINUE READING