One-pot synthesis of metalated pyridines from two acetylenes, a nitrile, and a titanium(II) alkoxide.

@article{Tanaka2005OnepotSO,
  title={One-pot synthesis of metalated pyridines from two acetylenes, a nitrile, and a titanium(II) alkoxide.},
  author={R. Tanaka and Akio Yuza and Yuko Watai and D. Suzuki and Y. Takayama and F. Sato and H. Urabe},
  journal={Journal of the American Chemical Society},
  year={2005},
  volume={127 21},
  pages={
          7774-80
        }
}
Four-component coupling process involving two acetylenes, a nitrile, and a divalent titanium alkoxide reagent, Ti(O-i-Pr)(4)/2i-PrMgCl, directly yielded titanated pyridines in a highly selective manner. The reaction can be classified into four categories: (i) a combination of an internal acetylene, a terminal acetylene, sulfonylnitrile, and the titanium reagent to yield alpha-titanated pyridines, (ii) a combination of an internal acetylene, a (sulfonylamino)acetylene, a nitrile, and the… Expand
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