One-pot synthesis of meso-alkyl substituted isocorroles: the reaction of a triarylcorrole with Grignard reagent.

@article{Nardis2010OnepotSO,
  title={One-pot synthesis of meso-alkyl substituted isocorroles: the reaction of a triarylcorrole with Grignard reagent.},
  author={Sara Nardis and Giuseppe Pomarico and Federica Mandoj and Frank R Fronczek and Kevin M Smith and Roberto Paolesse},
  journal={Journal of porphyrins and phthalocyanines},
  year={2010},
  volume={14 8},
  pages={752-757}
}
The reaction of 5,10,15-tritolylcorrole with EtMgBr opens the way for novel functionalizations of the corrole ring. DDQ oxidation of the macrocycle, followed by addition of the Grignard reagent, led to the formation of 5- and 10-alkyl substituted isocorroles in satisfying yields. Together with the one-pot formation of these isocorrole isomers, the use of… CONTINUE READING