One-pot synthesis of difluoromethyl ketones by a difluorination/fragmentation process.

Abstract

Difluoromethyl ketones are an under-studied class of ketones which have great potential as useful building blocks for materials and drug design. Here we report a simple and convenient synthesis of this class of compounds via a one-pot difluorination/fragmentation of 1-trifluoromethyl-1,3-diketones which should now allow the chemistry of difluoromethyl ketones to be fully developed.

DOI: 10.1039/c5ob02468d

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Cite this paper

@article{Leng2016OnepotSO, title={One-pot synthesis of difluoromethyl ketones by a difluorination/fragmentation process.}, author={Daniel J Leng and Conor M Black and Graham Pattison}, journal={Organic & biomolecular chemistry}, year={2016}, volume={14 5}, pages={1531-5} }