One-pot synthesis of 4,5-biphenyl-2-pyrimidinylguanidine derivatives.

  title={One-pot synthesis of 4,5-biphenyl-2-pyrimidinylguanidine derivatives.},
  author={Zun-ting Zhang and Fei-Fei Xu and Mi-xiang Gao and Li Qiu},
  journal={Journal of combinatorial chemistry},
  volume={11 5},
A simple and straightforward methodology toward the synthesis of novel 4,5-biphenyl-2-pyrimidinylguanidine compounds has been developed by one-pot reaction of biguaninde or dimethyldiguanide with isoflavones. A series of 20 new compounds was reported. All of them were characterized by FT-IR, NMR, and elemental analysis. A typical compound was determined by X-ray diffraction. A variety of substrates can participate in the process with good yields and high purities, making this methodology… Expand
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