One-pot syntheses of immunostimulatory glycolipids.

@article{Schombs2010OnepotSO,
  title={One-pot syntheses of immunostimulatory glycolipids.},
  author={Matthew W. Schombs and Francine E Park and Wenjun Du and Suvarn S Kulkarni and Jacquelyn Gervay-Hague},
  journal={The Journal of organic chemistry},
  year={2010},
  volume={75 15},
  pages={4891-8}
}
Glycolipids containing alpha-linked galactosyl and glucosyl moieties have been shown to possess unique immunostimulatory activity creating a need for access to diverse and anomerically pure sources of these compounds for immunological studies. To meet this demand, glycosyl iodides were enlisted in the synthesis of these biologically relevant glycoconjugates. In the first-generation protocol, per-O-benzyl galactosyl iodide was efficiently coupled with activated sphingosine acceptors, but fully… CONTINUE READING
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Chemical Glycobiology I : Glycoconjugates and CarbohydrateProtein Interactions

  • S. S. Kulkarni, J. Gervay-Hague
  • 2008

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