One-pot multicomponent synthesis of highly functionalized piperidines from substituted β-nitrostyrenes, Meldrum's acid, aromatic aldehydes, and ammonium acetate.

@article{Li2014OnepotMS,
  title={One-pot multicomponent synthesis of highly functionalized piperidines from substituted β-nitrostyrenes, Meldrum's acid, aromatic aldehydes, and ammonium acetate.},
  author={Yan Li and Zhiheng Xue and Weijian Ye and Juanjuan Liu and Juan Yao and Cunde Wang},
  journal={ACS combinatorial science},
  year={2014},
  volume={16 3},
  pages={
          113-9
        }
}
An efficient and straightforward synthetic protocol has been developed for the diversity-oriented synthesis of highly functionalized piperidines containing a Meldrum's acid moiety via pseudo five-component reaction between aromatic aldehydes, ammonium acetate, substituted β-nitrostyrenes and Meldrum's acid for the generation of a wide range of structurally interesting and pharmacologically significant compounds. 
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