One neuron-one receptor rule in the mouse olfactory system.

@article{Serizawa2004OneNR,
  title={One neuron-one receptor rule in the mouse olfactory system.},
  author={Shou Serizawa and Kazunari Miyamichi and Hitoshi Sakano},
  journal={Trends in genetics : TIG},
  year={2004},
  volume={20 12},
  pages={648-53}
}
Similar to the expression of antigen receptor genes in lymphocytes, the mammalian odorant receptor (OR) genes are expressed in a mutually exclusive and monoallelic manner in olfactory sensory neurons (OSNs). DNA rearrangement has long been regarded as a possible mechanism for the allelic exclusion of the OR genes. However, mice cloned from mature OSN nuclei expressed the full repertoire of ORs, and the possibility of irreversible gene translocation was excluded as a mechanism to activate a… CONTINUE READING

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