One molecule, many derivatives: A never‐ending interaction of melatonin with reactive oxygen and nitrogen species?

@article{Tan2007OneMM,
  title={One molecule, many derivatives: A never‐ending interaction of melatonin with reactive oxygen and nitrogen species?},
  author={Dun-Xian Tan and Lucien C. Manchester and Mar{\'i}a Pilar Terr{\'o}n and Luis J. Flores and Russel Joseph Reiter},
  journal={Journal of Pineal Research},
  year={2007},
  volume={42}
}
Abstract:  Melatonin is a highly conserved molecule. Its presence can be traced back to ancient photosynthetic prokaryotes. A primitive and primary function of melatonin is that it acts as a receptor‐independent free radical scavenger and a broad‐spectrum antioxidant. The receptor‐dependent functions of melatonin were subsequently acquired during evolution. In the current review, we focus on melatonin metabolism which includes the synthetic rate‐limiting enzymes, synthetic sites, potential… 
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