One molecule, many derivatives: A never‐ending interaction of melatonin with reactive oxygen and nitrogen species?

@article{Tan2007OneMM,
  title={One molecule, many derivatives: A never‐ending interaction of melatonin with reactive oxygen and nitrogen species?},
  author={D. Tan and L. Manchester and M. Terr{\'o}n and L. J. Flores and R. Reiter},
  journal={Journal of Pineal Research},
  year={2007},
  volume={42}
}
Abstract:  Melatonin is a highly conserved molecule. Its presence can be traced back to ancient photosynthetic prokaryotes. A primitive and primary function of melatonin is that it acts as a receptor‐independent free radical scavenger and a broad‐spectrum antioxidant. The receptor‐dependent functions of melatonin were subsequently acquired during evolution. In the current review, we focus on melatonin metabolism which includes the synthetic rate‐limiting enzymes, synthetic sites, potential… Expand
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