One-carbon metabolism related gene polymorphisms interact with alcohol drinking to influence the risk of colorectal cancer in Japan.

@article{Matsuo2005OnecarbonMR,
  title={One-carbon metabolism related gene polymorphisms interact with alcohol drinking to influence the risk of colorectal cancer in Japan.},
  author={Keitaro Matsuo and Hidemi Ito and Kenji Wakai and Kaoru Hirose and Toshiko Saito and Takeshi Suzuki and Tomoyuki Kato and Takashi Hirai and Yukihide Kanemitsu and Hiroshi Hamajima and Kazuo Tajima},
  journal={Carcinogenesis},
  year={2005},
  volume={26 12},
  pages={2164-71}
}
One-carbon metabolism, in which folate plays an essential role, is involved in DNA methylation and synthesis, and is suspected of impacting on colorectal carcinogenesis. Alcohol is well recognized as a risk factor for colorectal cancer (CRC) and interactions with one-carbon metabolism have also been suggested. Therefore, functional polymorphisms in genes encoding members of this pathway, MTHFR C677T and A1298C (genes for methylenetetrahydrofolate reductase), MTR A2756G (gene for methionine… CONTINUE READING
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