One-carbon metabolism-related gene polymorphisms and risk of head and neck squamous cell carcinoma: case-control study.

@article{Suzuki2007OnecarbonMG,
  title={One-carbon metabolism-related gene polymorphisms and risk of head and neck squamous cell carcinoma: case-control study.},
  author={Takeshi Suzuki and Keitaro Matsuo and Yasuhisa Hasegawa and Akio Hiraki and Kenji Wakai and Kaoru Hirose and Toshiko Saito and Shigeki Sato and Ryuzo Ueda and Kazuo Tajima},
  journal={Cancer science},
  year={2007},
  volume={98 9},
  pages={
          1439-46
        }
}
Low consumption of vegetables and fruits, which leads to insufficient folate intake, is associated with increased risk of several types of cancer, including head and neck squamous cell carcinoma (HNSCC). Functional polymorphisms in genes encoding one-carbon metabolism enzymes, such as methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), methionine synthase (MTR A2756G), methionine synthase reductase (MTRR A66G) and thymidylate synthase (TS), influence folate metabolism and thus might… CONTINUE READING

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