One- and two-photon excited optical ph probing for cells using surface-enhanced Raman and hyper-Raman nanosensors.

@article{Kneipp2007OneAT,
  title={One- and two-photon excited optical ph probing for cells using surface-enhanced Raman and hyper-Raman nanosensors.},
  author={Janina Kneipp and Harald Kneipp and Burghardt Wittig and Katrin Kneipp},
  journal={Nano letters},
  year={2007},
  volume={7 9},
  pages={2819-23}
}
We demonstrate spatially resolved probing and imaging of pH in live cells by mobile and biocompatible nanosensors using surface-enhanced Raman scattering (SERS) of 4-mercaptobenzoic acid (pMBA) on gold nanoaggregates. Moreover, we also show that this concept of pH nanosensors can be extended to two-photon excitation by using surface-enhanced hyper-Raman scattering (SEHRS). In addition to the advantages of two-photon excitation, the SEHRS sensor enables measurements over a wide pH range without… CONTINUE READING

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