One- and two-electron oxidation of thiols: mechanisms, kinetics and biological fates.

@article{Trujillo2016OneAT,
  title={One- and two-electron oxidation of thiols: mechanisms, kinetics and biological fates.},
  author={M Ligia Trujillo and Beatriz {\'A}lvarez and Rafael Radi},
  journal={Free radical research},
  year={2016},
  volume={50 2},
  pages={
          150-71
        }
}
The oxidation of biothiols participates not only in the defense against oxidative damage but also in enzymatic catalytic mechanisms and signal transduction processes. Thiols are versatile reductants that react with oxidizing species by one- and two-electron mechanisms, leading to thiyl radicals and sulfenic acids, respectively. These intermediates, depending on the conditions, participate in further reactions that converge on different stable products. Through this review, we will describe the… CONTINUE READING
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