One- and two-dimensional 1H NMR, fluorescence, and molecular modeling studies on the tomaymycin-d(ATGCAT)2 adduct. Evidence for two covalent adducts with opposite orientations and stereochemistries at the covalent linkage site.

@article{Cheatham1988OneAT,
  title={One- and two-dimensional 1H NMR, fluorescence, and molecular modeling studies on the tomaymycin-d(ATGCAT)2 adduct. Evidence for two covalent adducts with opposite orientations and stereochemistries at the covalent linkage site.},
  author={S. Cheatham and A. Kook and L. Hurley and M. Barkley and W. Remers},
  journal={Journal of medicinal chemistry},
  year={1988},
  volume={31 3},
  pages={
          583-90
        }
}
  • S. Cheatham, A. Kook, +2 authors W. Remers
  • Published 1988
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • Tomaymycin is a member of the pyrrolo[1,4]benzodiazepine antitumor-antibiotic group that binds covalently to the exocyclic 2-amino group of guanine in DNA. Previous correlation of fluorescence and NMR data suggested that the 11R,11aS and the 11S,11aS diastereomers of tomaymycin could bind to DNA in two orientations relative to the covalently modified guanine (Barkley, M. D.; Cheatham, S.; Thurston, D. E.; Hurley, L. H. Biochemistry 1986, 25, 3021-3031). We now report on fluorescence, one- and… CONTINUE READING
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