One SUMO is sufficient to silence the dimeric potassium channel K2P1.

@article{Plant2010OneSI,
  title={One SUMO is sufficient to silence the dimeric potassium channel K2P1.},
  author={Leigh D Plant and Irina S. Dementieva and Astrid Kollewe and Sonia Olikara and Jeremy D Marks and Steve An Goldstein},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 23},
  pages={10743-8}
}
Small ubiquitin modifier 1 (SUMO1) is shown to regulate K2P1 background channels in the plasma membrane (PM) of live mammalian cells. Confocal microscopy reveals native SUMO1, SAE1, and Ubc9 (the enzymes that activate and conjugate SUMO1) at PM where SUMO1 and expressed human K2P1 are demonstrated to colocalize. Silent K2P1 channels in excised PM patches are activated by SUMO isopeptidase (SENP1) and resilenced by SUMO1. K2P1-Lys274 is crucial: when mutated to Gln, Arg, Glu, Asp, Cys, or Ala… CONTINUE READING