Ondansetron reduces chemotherapy induced nausea and vomiting refractory to standard antiemetics.

@article{Mitchell1992OndansetronRC,
  title={Ondansetron reduces chemotherapy induced nausea and vomiting refractory to standard antiemetics.},
  author={Paul L. R. Mitchell and B. D. Evans and Simon G. Allan and Gary V. Forgeson and Dora Mak and Lorraine M. Neave and G P Humm and G. Langley and Daniel Dickson and Vernon J. Harvey},
  journal={The New Zealand medical journal},
  year={1992},
  volume={105 929},
  pages={73-5}
}
Ondansetron, a selective 5HT3 (serotonin) antagonist, was used in patients refractory to standard antiemetics. Seventy-five patients receiving chemotherapy without cisplatin were given ondansetron 4 mg IV and 4 mg orally immediately prior to chemotherapy, then 8 mg orally after six and 12 hours, followed by 8 mg orally eight hourly during days 2-5. Complete control of vomiting occurred in 52 patients (69%) on the first day and 45 patients (60%) on days 2-5. Sixty patients (80%) preferred… CONTINUE READING

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