Ondansetron compared with high-dose metoclopramide in prophylaxis of acute and delayed cisplatin-induced nausea and vomiting. A multicenter, randomized, double-blind, crossover study.

@article{Mulder1990OndansetronCW,
  title={Ondansetron compared with high-dose metoclopramide in prophylaxis of acute and delayed cisplatin-induced nausea and vomiting. A multicenter, randomized, double-blind, crossover study.},
  author={Pieter H M de Mulder and Caroline S Seynaeve and Jan Baptist Vermorken and P A van Liessum and S Mols-Jevdevic and Eric Allman and P A Beranek and Jaap Verweij},
  journal={Annals of internal medicine},
  year={1990},
  volume={113 11},
  pages={834-40}
}
OBJECTIVE To compare the efficacy and side effects of ondansetron with those of high-dose metoclopramide in treating acute and delayed cisplatin-induced nausea and vomiting. DESIGN Randomized, double-blind, crossover trial. SETTING Conducted at two university hospitals, a cancer institute, and six community hospitals. PATIENTS Of 125 patients, 95 were evaluable for the acute phase and 79 for the delayed phase. Major reasons for not being evaluable were no second course (14 patients… CONTINUE READING

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