Ondansetron HCl Microemulsions for Transdermal Delivery: Formulation and In Vitro Skin Permeation

@inproceedings{Malakar2012OndansetronHM,
  title={Ondansetron HCl Microemulsions for Transdermal Delivery: Formulation and In Vitro Skin Permeation},
  author={Jadupati Malakar and Amit Kumar Nayak and Aalok Basu},
  booktitle={ISRN pharmaceutics},
  year={2012}
}
Ondansetron HCl delivery through oral route suffers due to its low bioavailability due to first-pass metabolism. Therefore, the microemulsion-based transdermal delivery may be a better substitute for it. The pseudoternary phase diagrams were constructed to determine compositions of microemulsions, and ondansetron HCl microemulsions for transdermal delivery were developed using isopropyl myristate or oleic acid as the oil phase, Tween 80 as the surfactant, and isopropyl alcohol as the… CONTINUE READING
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