Ondansetron, a 5-HT3 antagonist, improves cerebellar tremor.

  title={Ondansetron, a 5-HT3 antagonist, improves cerebellar tremor.},
  author={George P. Rice and J Lesaux and Pieter Vandervoort and L Macewan and George Cornell Ebers},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  volume={62 3},
It has been previously shown that ondansetron, a 5-HT3 antagonist, can ameliorate vertigo in patients with acute brainstem disorders. A coincidental benefit was the improvement of cerebellar tremor in some patients with both vertigo and tremor. To further evaluate this effect, a placebo controlled, double blind, crossover study was conducted of a single dose of intravenous ondansetron in 20 patients with cerebellar tremor caused by multiple sclerosis, cerebellar degeneration, or drug toxicity… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 23 extracted citations

Effects of the oral form of ondansetron on cerebellar dysfunction

Journal of Neurology • 2003
View 10 Excerpts
Highly Influenced

Progressive Multiple Sclerosis

Springer International Publishing • 2018

Mechanisms and Emerging Therapies in Tremor Disorders

Contemporary Clinical Neuroscience • 2013


Publications referenced by this paper.
Showing 1-10 of 11 references

A case of rare side effects of certain antidepressive drugs

T Haenel, HR Stockli, P Truog
Nervenarzt • 1995

The cerebellar serotoninergic system and its possible involvement in cerebellar ataxia.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques • 1993

Effect of thiamine deficiency on brain serotonin turnover

MH VanWoert, A Plaitakis, EC Hwang, S Berl
Brain Res • 1979

Similar Papers

Loading similar papers…