Ondansetron, a 5-HT3 antagonist, improves cerebellar tremor.

@article{Rice1997OndansetronA5,
  title={Ondansetron, a 5-HT3 antagonist, improves cerebellar tremor.},
  author={George P. Rice and J Lesaux and Pieter Vandervoort and L Macewan and George Cornell Ebers},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  year={1997},
  volume={62 3},
  pages={282-4}
}
It has been previously shown that ondansetron, a 5-HT3 antagonist, can ameliorate vertigo in patients with acute brainstem disorders. A coincidental benefit was the improvement of cerebellar tremor in some patients with both vertigo and tremor. To further evaluate this effect, a placebo controlled, double blind, crossover study was conducted of a single dose of intravenous ondansetron in 20 patients with cerebellar tremor caused by multiple sclerosis, cerebellar degeneration, or drug toxicity… CONTINUE READING

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