Oncoviral bovine leukemia virus G4 and human T-cell leukemia virus type 1 p13(II) accessory proteins interact with farnesyl pyrophosphate synthetase.

@article{Lefbvre2002OncoviralBL,
  title={Oncoviral bovine leukemia virus G4 and human T-cell leukemia virus type 1 p13(II) accessory proteins interact with farnesyl pyrophosphate synthetase.},
  author={Laurent Lef{\`e}bvre and Alain Vanderplasschen and Vincenzo Ciminale and Hubertine Heremans and Olivier Dangoisse and Jean-Claude Jauniaux and J T Toussaint and Vlado Zelnik and Ars{\`e}ne Burny and Richard Kettmann and Luc Willems},
  journal={Journal of virology},
  year={2002},
  volume={76 3},
  pages={1400-14}
}
G4 and p13(II) are accessory proteins encoded by the X region of bovine leukemia virus and human T-cell leukemia virus type 1 (HTLV-1), respectively. Disruption of the G4 and p13(II) open reading frames interferes with viral spread in animal model systems, indicating that the corresponding proteins play a key role in viral replication. In addition, G4 is oncogenic in primary cell cultures and is absolutely required for efficient onset of leukemogenesis in sheep. To gain insight into the… CONTINUE READING