Oncostatin m modulates the mesenchymal-epithelial transition of lung adenocarcinoma cells by a mesenchymal stem cell-mediated paracrine effect.

@article{Wang2012OncostatinMM,
  title={Oncostatin m modulates the mesenchymal-epithelial transition of lung adenocarcinoma cells by a mesenchymal stem cell-mediated paracrine effect.},
  author={Mong-Lien Wang and Chih-Ming Pan and Shih-Hwa Chiou and Wen-Hsin Chen and Hsiang-Yi Chang and Oscar K Lee and Han-Sui Hsu and C Wu},
  journal={Cancer research},
  year={2012},
  volume={72 22},
  pages={6051-64}
}
Mesenchymal stem cells (MSC) are strongly associated with tumor progression and have been used as novel cell-based agents to deliver anticancer drugs to tumors. However, controversies about the direct involvement of MSCs in tumor progression suggest that MSCs mediate tumor progression in a cancer type-dependent manner. In this report, we analyzed the functional interactions between human MSCs and lung adenocarcinoma (LAC) cells to determine the therapeutic potential of MSCs in lung cancer. We… CONTINUE READING