Oncostatin m, an inflammatory cytokine produced by macrophages, supports intramembranous bone healing in a mouse model of tibia injury.

@article{Guihard2015OncostatinMA,
  title={Oncostatin m, an inflammatory cytokine produced by macrophages, supports intramembranous bone healing in a mouse model of tibia injury.},
  author={Pierre Guihard and Marie-Astrid Boutet and B{\'e}n{\'e}dicte Brounais-Le Royer and Anne-laure Gamblin and J{\'e}r{\^o}me Amiaud and Audrey Renaud and Martine Berreur and James E. Bradner and Dominique Heymann and Pierre Layrolle and Fr{\'e}d{\'e}ric Blanchard},
  journal={The American journal of pathology},
  year={2015},
  volume={185 3},
  pages={
          765-75
        }
}
Different macrophage depletion strategies have demonstrated a vital role of macrophages in bone healing, but the underlying molecular mechanisms are poorly understood. Here, with the use of a mouse model of tibia injury, we found that the cytokine oncostatin M [OSM or murine (m)OSM] was overexpressed during the initial inflammatory phase and that depletion of macrophages repressed mOSM expression. In Osm(-/-) mice, by micro-computed tomography and histology we observed a significant reduction… CONTINUE READING
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