Oncostatin M suppresses generation of lymphoid progenitors in fetal liver by inhibiting the hepatic microenvironment.

@article{Kinoshita2001OncostatinMS,
  title={Oncostatin M suppresses generation of lymphoid progenitors in fetal liver by inhibiting the hepatic microenvironment.},
  author={Tomoko Kinoshita and Kaoru Nagata and Noriko Sorimachi and Hajime Karasuyama and Takashi Sekiguchi and Atsushi Miyajima},
  journal={Experimental hematology},
  year={2001},
  volume={29 9},
  pages={1091-7}
}
OBJECTIVE Interaction between hematopoietic cells and stromal cells is important for regulation of hematopoiesis. Numerous soluble and membrane-bound factors directly regulating hematopoiesis have been documented, but little is known about how stromal cell activity is controlled. We previously reported that fetal hepatic cells in primary culture create the hematopoietic microenvironment and support expansion of blood cells from hematopoietic stem cells. In this study, we focused on… CONTINUE READING