Oncostatin M stimulates macrophage-polykaryon formation in long-term human bone-marrow cultures.

@article{Heymann1998OncostatinMS,
  title={Oncostatin M stimulates macrophage-polykaryon formation in long-term human bone-marrow cultures.},
  author={Dominique Heymann and J{\'e}r{\^o}me Guicheux and F. Gouin and M. Cottrel and Guy Daculsi},
  journal={Cytokine},
  year={1998},
  volume={10 2},
  pages={98-109}
}
Though oncostatin M (OSM) is a potent mediator of the inflammatory reaction, its role in inflammation and bone resorption is still unclear. A long-term bone-marrow culture system is usually developed to allow the formation of multinucleated cells (MNC) and was used here to define the effects of human recombinant OSM on human MNC formation. OSM significantly upregulated (1.9- to 5.6-fold) the number of MNC in these cultures in a dose- and time-dependent manner. Cell nucleation and tartrate… CONTINUE READING