Oncostatin M protects against demyelination by inducing a protective microglial phenotype.

@article{Janssens2015OncostatinMP,
  title={Oncostatin M protects against demyelination by inducing a protective microglial phenotype.},
  author={Kris Janssens and Anurag Maheshwari and Chris Van Van den Haute and Veerle Baekelandt and Piet Stinissen and Jerome J A Hendriks and Helena Slaets and Niels Hellings},
  journal={Glia},
  year={2015},
  volume={63 10},
  pages={1729-37}
}
Multiple sclerosis (MS) is a chronic disabling disease of the central nervous system (CNS), in which destruction of myelin sheaths leads to disturbed axonal conduction. Available MS therapies modulate the immune response, but are unable to prevent neurological decline. Therefore, great efforts are made to develop therapies that limit demyelination and axonal degeneration. Oncostatin M (OSM), a member of the interleukin (IL)-6 cytokine family, is produced in demyelinating lesions of MS patients… CONTINUE READING