Oncostatin M promotes STAT3 activation, VEGF production, and invasion in osteosarcoma cell lines

@inproceedings{Fossey2010OncostatinMP,
  title={Oncostatin M promotes STAT3 activation, VEGF production, and invasion in osteosarcoma cell lines},
  author={Stacey L Fossey and Misty D Bear and William C. Kisseberth and Michael Lindsey Pennell and Cheryl A London},
  booktitle={BMC Cancer},
  year={2010}
}
We have previously demonstrated that both canine and human OSA cell lines, as well as 8 fresh canine OSA tumor samples, exhibit constitutive phosphorylation of STAT3, and that this correlates with enhanced expression of matrix metalloproteinase-2 (MMP2). While multiple signal transduction pathways can result in phosphorylation of STAT3, stimulation of the cytokine receptor gp130 through either IL-6 or Oncostatin M (OSM) is the most common mechanism through which STAT3 is activated. The purpose… CONTINUE READING

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Oncostatin M, a multifunctional cytokine.

Reviews of physiology, biochemistry and pharmacology • 2003
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Highly Influenced

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