Oncostatin M induces growth arrest by inhibition of Skp2, Cks1, and cyclin A expression and induced p21 expression.

@article{Halfter2006OncostatinMI,
  title={Oncostatin M induces growth arrest by inhibition of Skp2, Cks1, and cyclin A expression and induced p21 expression.},
  author={Hartmut Halfter and Matthias M. Friedrich and Ansgar Resch and Michael Kullmann and Florian St{\"o}gbauer and Erich B. Ringelstein and Ludger Hengst},
  journal={Cancer research},
  year={2006},
  volume={66 13},
  pages={
          6530-9
        }
}
Oncostatin M has been characterized as a potent growth inhibitor for various tumor cells. Oncostatin M-treated glioblastoma cells cease proliferation and instigate astrocytal differentiation. The oncostatin M-induced cell cycle arrest in G(1) phase is characterized by increased level of the cyclin-dependent kinase (CDK) inhibitory proteins p21(Cip1/Waf1/Sdi1) and p27(Kip1). Induction of p21 protein corresponds to increased mRNA level, whereas p27 accumulates due to increased stability of the… CONTINUE READING

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