Oncostatin M and interleukin-31: Cytokines, receptors, signal transduction and physiology.

@article{Hermanns2015OncostatinMA,
  title={Oncostatin M and interleukin-31: Cytokines, receptors, signal transduction and physiology.},
  author={Heike M Hermanns},
  journal={Cytokine & growth factor reviews},
  year={2015},
  volume={26 5},
  pages={545-58}
}
Oncostatin M (OSM) and interleukin-31 (IL-31) are two cytokines belonging to the IL-6 family which share a common signaling receptor subunit, the OSM receptor beta (OSMRβ). Both of them are released by monocytes/macrophages, dendritic cells and T lymphocytes in inflammatory situations and upon binding to their respective receptor complexes they signal mainly via the JAK/STAT pathway. Besides sharing many biochemical properties, both display divergent physiological functions. This review… CONTINUE READING
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