Oncostatin M activates phosphatidylinositol-3-kinase in Kaposi's sarcoma cells.

  title={Oncostatin M activates phosphatidylinositol-3-kinase in Kaposi's sarcoma cells.},
  author={Roberto de Mattos Soldi and Andrea Graziani and Roberto Benelli and Dario Ghigo and Amalia Bosia and Adriana Albini and Federico Bussolino},
  volume={9 8},
Oncostatin M (OM) is a polypeptide cytokine that induces autocrine and paracrine effects on AIDS-Kaposi's sarcoma (KS) cells (Nair et al., Science, 255, 1430-1432, 1992; Miles et al., Science, 255, 1432-1434, 1992). The signalling pathways underlying this activation are largely unknown. We have found that OM binding to KS cell lines in vitro identifies a higher affinity binding site (Kd 10-20 pM) with a lower affinity (Kd 1.5 nM), high capacity binding site. The binding of OM to its receptor at… CONTINUE READING
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